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A Novel and Highly Regioselective Route to Construct Methylthio-Substituted Pyridazines from Aryl Methyl Ketones at Room Temperature

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成果类型:
期刊论文
作者:
Wu, Luming;Yang, Yan;Gao, Meng;Zhang, Dongxue;Shu, Wenming;...
通讯作者:
Wu, Anxin(吴安心
作者机构:
[Wu, Anxin; Shu, Wenming; Zhu, Yanping; Gao, Meng; Yang, Yan; Zhang, Dongxue; Wu, Luming] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, Anxin] C
Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
regioselectivity;homocoupling/cyclization;aryl methyl ketones;hydrazine hydrate;methylthio-substituted pyridazine
期刊:
SYNLETT
ISSN:
0936-5214
年:
2012
卷:
23
期:
14
页码:
2137-2141
基金类别:
Central China Normal University; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21032001]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A novel and highly regioselective two-step homocoupling/cyclization procedure from easily available aryl methyl ketones and hydrazine hydrate was developed for the synthesis of methylthio-substituted pyridazines at room temperature. The method has remarkable advantages owing to the simple substrates, mild reaction conditions, ease of manipulation, good yields and high regioselec...

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