[Zhao, Wei; Yang, Xu] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.
通讯机构：
[Yang, Xu] H
[Yang, Xu] C
Hubei Univ Sci & Technol, Xianning, Peoples R China.
Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.
语种：
英文
关键词：
Fe3O4 nanoparticle;Kunming mice;biosafety;lung
期刊：
Ferroelectrics
ISSN：
0015-0193
年：
2018
卷：
527
期：
1
页码：
44-51
会议名称：
Joint Symposium of the 8th International Conference of th Chinese-Society-of-Micro-Nano-Technology (CSMNT) / Microsystems and Nanoengineering Summit (MAN) / Symposium of Materials Science and Technology (SOMST)
会议时间：
OCT 13-16, 2017
会议地点：
Tianjin, PEOPLES R CHINA
会议主办单位：
[Huang, Xiaoxiao;Rao, Yan] Wuhan Sports Univ, Coll Art, Wuhan, Hubei, Peoples R China.^[Ma, Ping;Yang, Xu] Hubei Univ Sci & Technol, Xianning, Peoples R China.^[Zhao, Wei;Yang, Xu] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.
会议赞助商：
Chinese Soc Micro Nano Technol, Chinese Soc Mat Res, Youth Work Comm, Tianjin Univ
出版地：
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
This work was funded by the Science and Technology Research Foundation from Hubei Province Education Department (Q20152801).
机构署名：
本校为通讯机构
院系归属：
生命科学学院
摘要：
To investigate the potential oxidative damages of Fe3O4nanoparticles to organisms, Kunming mice were intraperitoneally administrated with Fe3O4nanoparticles for seven days at the doses of 5, 10, 20 and 40 mg·kg−1, respectively. The contents of ROS (reactive oxygen species), GSH (glutathione) and MDA (malondialdehyde) in the lung homogenate were measured to indicate the oxidative damage. Results showed that the contents of ROS and MDA increased gradually while GSH content decreased with the increase in exposure dose, and all the studied biomarkers changed in dose-response mann...
