Design and syntheses of novel N′-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide as inhibitors of cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase

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成果类型：

期刊论文

作者：

Tu, Qi-Dong;Li, Ding;Sun, Yao;Han, Xin-Ya;Yi, Fan;...

通讯作者：

Feng, Ling-Ling（冯玲玲）

作者机构：

[Feng, Ling-Ling; Tu, Qi-Dong; Ren, Yan-Liang; Wan, Jian; Ding, Ming-Wu; Sun, Yao; Han, Xin-Ya; Yi, Fan; Sha, Yibamu; Li, Ding] Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.

[Feng, Ling-Ling; Tu, Qi-Dong; Ren, Yan-Liang; Wan, Jian; Ding, Ming-Wu; Sun, Yao; Han, Xin-Ya; Yi, Fan; Sha, Yibamu; Li, Ding] Cent China Normal Univ, Dept Chem, Wuhan 430079, Peoples R China.

[Tu, Qi-Dong] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China.

通讯机构：

[Feng, Ling-Ling] M

Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

Benzohydrazone;Chromone;Cyanobacteria harmful algal blooms;Inhibitory activity

期刊：

Bioorganic & Medicinal Chemistry

ISSN：

0968-0896

年：

2013

卷：

期：

页码：

2826-2831

DOI：

10.1016/j.bmc.2013.04.003

基金类别：

National Basic Research Program of China (973 Program)National Basic Research Program of China [2010CB126100]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21202056, 21272089, 21172089, 21072073, 20873049]; PCSIRTProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT0953]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2010CDB01202]; Program for Academic leader in Wuhan Municipality [201150530150]; self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU10C01002, CCNU10A02006]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphoshatase (Cy-FBP/SBPase) is an important target enzyme for finding inhibitors to solve harmful algal bloom (HAB). In this study, as potential inhibitors of Cy-FBP/SBPase, a series of novel chromone-connecting benzohydrazone compounds (Novel N′-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide) were designed and synthesized. Their inhibitory activities against Cy-FBP/SBPase were further examined in vitro. Some of these compounds, such as f6-f8, f11, f12 and f16, exhibit higher inhibitory activi...

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Design and syntheses of novel N′-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide as inhibitors of cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase

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