期刊论文

Lu, Liang-Qiu

英文

Chemical Communications

1359-7345

2019

55

60

8716-8721

10.1039/c9cc02831e

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21822103, 21820102003, 21772052, 21772053, 21572074, 21472057]; Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2017AHB047]; International Joint Research Center for Intelligent Biosensing Technology and Health

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The Wittig reaction is a reliable method for synthesizing alkenes from phosphorous ylides (P-ylides) and carbonyls, and is thus widely applied in medicine and pharmaceutical production. Among them, asymmetric Wittig reactions using chiral P-ylides are believed to be a conventional pathway towards chiral alkenes. Obviously, the key of this transformation is the efficient construction of chiral P-ylides. Over the past decade, the coupling of the in situ generated chiral P-ylides through the catalytic asymmetric alkylation of easily available P-ylides and the subsequent Wittig reaction with carbo...