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"Anion clamp'' allows flexible protein to impose coordination geometry on metal ions

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成果类型:
期刊论文
作者:
Wang, Minji;Lai, Tsz Pui;Wang, Li;Zhang, Hongmin;Yang, Nan;...
通讯作者:
Sun, Hongzhe
作者机构:
[Wang, Minji; Wang, Li; Sadler, Peter J.; Zhang, Hongmin; Sun, Hongzhe; Lai, Tsz Pui; Yang, Nan] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China.
[Wang, Li] Cent China Normal Univ, Dept Chem, Wuhan 430079, Hubei Province, Peoples R China.
[Zhang, Hongmin] South Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Peoples R China.
[Zhang, Hongmin] South Univ Sci & Technol China, Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China.
[Yang, Nan] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21287 USA.
通讯机构:
[Sun, Hongzhe] U
Univ Hong Kong, Dept Chem, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2015
卷:
51
期:
37
页码:
7867-7870
基金类别:
Council of Hong KongHong Kong Research Grants Council [705310P]; European Research CouncilEuropean Research Council (ERC)European Commission [247450]; University of Hong KongUniversity of Hong Kong; Shenzhen [ZDSYS20140509142721429]
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
X-ray crystal structures of human serum transferrin (77 kDa) with YbIII or FeIII bound to the C-lobe and malonate as the synergistic anion show that the large YbIII ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion....

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