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DNA damage by copper(II) complexes: coordination-structural dependence of reactivities

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成果类型:
期刊论文
作者:
Liu, CL*;Zhou, JY;Li, QX;Wang, LJ;Liao, ZR;...
通讯作者:
Liu, CL
作者机构:
[Liu, CL] Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China.
Cent China Normal Univ, Dept Chem, Wuhan 430070, Peoples R China.
通讯机构:
[Liu, CL] H
Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China.
语种:
英文
关键词:
Copper complexes;DNA damage;Hydroxyl radicals;Structural dependence
期刊:
Journal of Inorganic Biochemistry
ISSN:
0162-0134
年:
1999
卷:
75
期:
3
页码:
233-240
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
A variety of copper complexes with different structural features have been shown to bind double-helical DNA with binding constants of 10~4-10~7 M~(-1) and to promote double-strand DNA damage upon reductant/H_2O_2 activation. The interaction of the Cu complex with DNA results in hyperchromism and shifts to longer wavelengths of the strongest transitions in the Cu complexes, as well as striking hypochromism or hyperchromism of DNA absorption at 260nm. In the presence of DMPO as the spin trap, the solution of each copper complex exhibits typical four-line ESR spectra of the hydroxyl radical by ad...

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