Mep50 is essential for embryonic development in medaka fish

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yao, Qiting;Duan, Shi;Yang, Qing;Ma, Xiaoqin;Li, Zhenyu;...

通讯作者：

Haobin Zhao

作者机构：

[Duan, Shi; Ma, Xiaoqin; Chang, Pei; Zhong, Xueping; Yao, Qiting; Li, Zhenyu; Wu, Kongyue; Wang, Zequn; Yang, Qing; Zhou, Qingchun; Zhao, Haobin] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Cao, Mengxi] Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent T, Wuhan 430056, Peoples R China.

[Chen, Xinhua] Fujian Agr & Forestry Univ, Inst Oceanol, Key Lab Marine Biotechnol Fujian Prov, Fuzhou 350002, Peoples R China.

通讯机构：

[Haobin Zhao] H

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China

语种：

英文

关键词：

Apoptosis;CRISPR-Cas9;Embryonic development;Medaka;Mep50;Stemness

期刊：

Gene

ISSN：

0378-1119

年：

2023

卷：

868

页码：

147387

DOI：

10.1016/j.gene.2023.147387

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 31672284, 31272645 to HZ), the Open Fund of Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances (Grant No. PTS2021-01 to QZ), and the Project of Hubei Key Laboratory of Genetic Regulation and Integrative Biology (Grant No. GRIB202216 to HZ).

机构署名：

本校为第一机构

院系归属：

生命科学学院

摘要：

Mep50 as a partner promotes the activity and substrate affinity of Prmt5. Prmt5 and Mep50 function together in multiple bioprocesses of the cells. Both Prmt5 and Mep50 are necessary for maintenance of the stem cells and are indispensable in the embryogenesis in the mammals. However, the role of Mep50 is rarely studied in fish. This study was to investigate the role of Mep50 in embryonic development of medaka. Medaka mep50 was mutated by genomic editing with CRISPR-Cas9 technology. Two mutants with a deletion of 22 and 46 bp separately in mep50 caused premature stopping of translation. The homo...

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Mep50 is essential for embryonic development in medaka fish

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