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Stability and Hopf bifurcation of a tumor–immune system interaction model with an immune checkpoint inhibitor

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成果类型:
期刊论文
作者:
Shi, Shujing;Huang, Jicai;Kuang, Yang;Ruan, Shigui
通讯作者:
Huang, JC;Ruan, SG
作者机构:
[Shi, Shujing] Hangzhou Dianzi Univ, Sch Sci, Hangzhou 310018, Zhejiang, Peoples R China.
[Shi, Shujing; Huang, Jicai] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.
[Kuang, Yang] Arizona State Univ, Sch Math & Stat Sci, Tempe, AZ 85287 USA.
[Ruan, Shigui] Univ Miami, Dept Math, Coral Gables, FL 33146 USA.
通讯机构:
[Huang, JC ] C
[Ruan, SG ] U
Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.
Univ Miami, Dept Math, Coral Gables, FL 33146 USA.
语种:
英文
关键词:
Anti-PD-1;Hopf bifurcation;Immunotherapy;Periodic orbit;Stability;Tumor–immune system interaction model
期刊:
Communications in Nonlinear Science and Numerical Simulation
ISSN:
1007-5704
年:
2023
卷:
118
页码:
106996
基金类别:
Research was partially supported by NSFC, China (No. 11871235 , No. 11771168 ).
机构署名:
本校为通讯机构
院系归属:
数学与统计学学院
摘要:
In this paper we study a three-dimensional tumor-immune system interaction model consisted of tumor cells, activated T cells, and immune checkpoint inhibitor anti-PD-1. Based on the uncontrollable character of tumor cells in the absence of immune response and treatment, the growth of tumor cells is assumed to be exponential. We discuss the distribution of equilibria qualitatively and study the stability of all possible equilibria with and without anti-PD-1 drug. When no drug is applied, the model has a tumor-free equilibrium and at most one tumorous equilibrium. Biologically, there exists a th...

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