期刊论文

Du, Dan

英文

Talanta

0039-9140

2013

114

261-267

10.1016/j.talanta.2013.06.012

CDC/NIOSHUnited States Department of Health & Human ServicesCenters for Disease Control & Prevention - USANational Institute for Occupational Safety & Health (NIOSH) [R01 OH008173-01]; US-DOEUnited States Department of Energy (DOE) [DE-AC05-76RL01830]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21075047, 21275062]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-0871]; China Scholarship Council (CSC)China Scholarship Council; PNNL; NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTHUnited States Department of Health & Human ServicesCenters for Disease Control & Prevention - USANational Institute for Occupational Safety & Health (NIOSH) [R01OH008173, R01OH008173, R01OH008173, R01OH008173, R01OH008173, R01OH008173, R01OH008173, R01OH008173, R01OH008173] Funding Source: NIH RePORTER

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A portable immunochromatographic strip-based biosensor for direct detection of trichloropyridinol (TCP), a specific biomarker of exposure to chlorpyrifos, in human saliva sample is presented. In this approach, a series of immunoreactions was performed on the test strip, where the targeted analytes (TCP) bound to the Au nanoparticles-labeled antibodies on the conjugate pad to form analyte-Au-antibody conjugates, and then free Au-labeled antibodies were captured by TCP-BSA in the test zone. Captured Au nanoparticles, increased with decreased levels of analytes, can be observed visibly without an...