Network Analysis Reveals the Recognition Mechanism for Dimer Formation of Bulb-type Lectins

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Yunjie;Jian, Yiren;Liu, Zhichao;Liu, Hang;Liu, Qin;...

通讯作者：

Zeng, Chen

作者机构：

[Zhao, Yunjie] Cent China Normal Univ, Inst Biophys, Wuhan 430079, Peoples R China.

[Zhao, Yunjie] Cent China Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.

[Li, Zhangyong; Wang, Lu; Zeng, Chen] Chongqing Univ Posts & Telecommun, Res Ctr Biomed Engn, Chongqing 400065, Peoples R China.

[Liu, Zhichao; Jian, Yiren; Zeng, Chen; Zhao, Yunjie] George Washington Univ, Dept Phys, Washington, DC 20052 USA.

[Liu, Hang; Huang, H. Howie] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA.

通讯机构：

[Zeng, Chen] C

[Zeng, Chen] G

[Zeng, Chen] J

Chongqing Univ Posts & Telecommun, Res Ctr Biomed Engn, Chongqing 400065, Peoples R China.

George Washington Univ, Dept Phys, Washington, DC 20052 USA.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2017

卷：

期：

页码：

2876

DOI：

10.1038/s41598-017-03003-5

基金类别：

National Science Foundation (NSF)National Science Foundation (NSF) [0941228, CAREER 1350766, 1618706]; Scientific Research Foundation of Central China Normal University [20205170045]

机构署名：

本校为第一机构

院系归属：

物理科学与技术学院

心理学院

摘要：

The bulb-type lectins are proteins consist of three sequential beta-sheet subdomains that bind to specific carbohydrates to perform certain biological functions. The active states of most bulb-type lectins are dimeric and it is thus important to elucidate the short- and long-range recognition mechanism for this dimer formation. To do so, we perform comparative sequence analysis for the single- and double-domain bulb-type lectins abundant in plant genomes. In contrast to the dimer complex of two single-domain lectins formed via protein-protein interactions, the double-domain lectin fuses two si...

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Network Analysis Reveals the Recognition Mechanism for Dimer Formation of Bulb-type Lectins

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