Liquid biopsy of circulating tumor DNA and biosensor applications

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Xuanying;Ye, Mengsha;Zhang, Weiying;Tan, Duo;Jaffrezic-Renault, Nicole;...

通讯作者：

Guo, Zhenzhong

作者机构：

[Li, Xuanying; Tan, Duo; Ye, Mengsha; Guo, Zhenzhong] Wuhan Univ Sci & Technol, Coll Med, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Hubei, Peoples R China.

[Zhang, Weiying] Jianghan Univ, Inst Interdisciplinary Res, Key Lab Optoelect Chem Mat & Devices, Minist Educ, Wuhan 430056, Hubei, Peoples R China.

[Jaffrezic-Renault, Nicole] Univ Lyon, UMR CNRS 5280, Inst Analyt Sci, 5 La Doua St, F-69100 Villeurbanne, France.

[Yang, Xu] Cent China Normal Univ, Sch Life Sci, Lab Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Guo, Zhenzhong] W

Wuhan Univ Sci & Technol, Coll Med, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Hubei, Peoples R China.

语种：

英文

关键词：

Bioreceptor;Biosensor;Biotransducer;Circulating tumor DNA;Liquid biopsy;Signal amplification strategies

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2019

卷：

126

页码：

596-607

DOI：

10.1016/j.bios.2018.11.037

基金类别：

Z.G. thanks the “ChuTian Scholar” Project Award support, Hubei Province, PR China. D.T. thanks the 2017 Hubei Provincial Ministry of Education Innovation Project of undergraduate students (201710488046).

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Circulating tumor DNA (ctDNA) as a class of liquid biopsy is a type of gene fragment that contains tumor-specific gene changes in body fluids such as human peripheral blood. More and more evidences show that ctDNA is an excellent tumor biomarker for diagnosis, prognosis, tumor heterogeneity and so on. ctDNA is a tumor code in the blood. Liquid biopsy of ctDNA is firstly summarized. Compared with the traditional detection technologies of ctDNA, the biosensor is an excellent choice for the detection of ctDNA because of its portability, sensitivity, specificity and ease of use. This review mainly...

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Liquid biopsy of circulating tumor DNA and biosensor applications

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