期刊论文

Wei Huang<&wdkj&>Ge-Fei Hao<&wdkj&>Guang-Fu Yang

英文

BRIEFINGS IN BIOINFORMATICS

1467-5463

2022

23

4

10.1093/bib/bbac203

National Key Research and Development Program of China (2021YFD1700102), the National Natural Science Foundation of China (32125033), and the Key Research and Development Program of Hubei Province, China (2020BCB042). Program of Introducing Talents of Discipline to Universities of China (111 Program, D20023) and the Key Research and Development Program of Hubei Province, China (2020BCB042).

本校为第一机构

Protein kinases play crucial roles in many cellular signaling processes, making them become important targets for drug discovery. But drug resistance mediated by mutation puts a barrier to the therapeutic effect of kinase inhibitors. Fragment-based drug discovery has been successfully applied to overcome such resistance. However, the complicate kinase-inhibitor fragment interaction and fragment-to-lead process seriously limit the efficiency of kinase inhibitor discovery against resistance caused by mutation. Here, we constructed a comprehensive web platform KinaFrag for the fragment-based kina...