Endemic goiter, a worldwide endemic disease which relates to geo-chemical environmental factors, has a very long prevalent history in China. This thesis discusses the below four issues by analyzing a large amount of Chinese historical document. 1. Ancient Chinese descriptions on endemic goiter's symptoms As early as 2 500 years before present, Chinese knew the facts that endemic goiter distributes mostly in mountainous areas and prevails mainly in female population. In Chinese historical documents, goiter was called 'Ying' (goiter) at first, and then 'big-neck'. According to modern medicine, '...