Engineered Metallacycle-Based Supramolecular Photosensitizers for Effective Photodynamic Therapy

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成果类型：

期刊论文

作者：

Tu, Le;Li, Chonglu;Xiong, Xiaoxing;Kim, Ji Hyeon;Li, Qian;...

通讯作者：

Sun, Yao(sunyaogbasp@ccnu.edu.cn);Seung Kim, Jong(jongskim@korea.ac.kr)

作者机构：

[Tu, Le; Mei, Longcan; Li, Junrong; Sun, Yao; Li, Chonglu] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

[Xiong, Xiaoxing] Wuhan Univ, Dept Neurosurg, Renmin Hosp, Wuhan 430060, Peoples R China.

[Kim, Jong Seung; Kim, Ji Hyeon] Korea Univ, Dept Chem, Seoul 02841, South Korea.

[Li, Qian] Qingdao Univ Sci & Technol, Key Lab Opt Elect Sensing & Analyt Chem Life Sci, Qingdao 266100, Peoples R China.

[Liu, Shuang] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China.

通讯机构：

[Prof. Jong Seung Kim] D

[Prof. Yao Sun] N

National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, 430079 China<&wdkj&>Department of Chemistry, Korea University, Seoul, 02841 Korea

语种：

英文

关键词：

Anticancer;Molecular Engineering;Photodynamic Therapy;RuII Metallacycle;Supramolecular Chemistry

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN：

1433-7851

年：

2023

卷：

期：

页码：

e202301560-

DOI：

10.1002/anie.202301560

基金类别：

National Natural Science Foundation of China [22022404, 22074050, 21904103]; National Natural Science Foundation of Hubei Province [2022CFA033]; Fundamental Research Funds for the Central Universities [CCNU22QN007, WUT:2020IVB046]; Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MO [M2022-5]; Open Project Program of Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology [OHIC2022K02]; National Research Foundation of Korea [2018R1A3B1052702, 2019H1A2A1074096]

机构署名：

本校为第一机构

院系归属：

化学学院

摘要：

Although metallacycle‐based supramolecular photosensitizers (PSs) attracted increasing attention in biomedicine, their clinical translation is still hindered by their inherent dark toxicity. Herein, we report what to our knowledge is the first example of a molecular engineering approach to building blocks of metallacycles for constructing a series of supramolecular PSs (RuA–RuD), with the aim of simultaneously reducing dark toxicity and enhancing phototoxicity, and consequently obtaining high phototoxicity indexes (PI). Detailed in vitro inve...

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Engineered Metallacycle-Based Supramolecular Photosensitizers for Effective Photodynamic Therapy

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