Noise widely exists in animals and human everyday life, it has negative influence on animals from invertebrates to mammals, and even human beings. High level noise can cause damage to auditory structure and function, decrease auditory neural sensitivity and behavioral acuity, and even lead to noise-induced hearing loss (NIHL). In this review, we summarized influence impacts and classification of NIHL, and possible mechanisms underlying the NIHL. Previous research on NIHL showed that the NIHL was related to postsynaptic terminals swelling, reversible excitotoxicity induced by glutamate and reac...