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噪声所致听力损失现象的物种差异及可能生理机制研究进展

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成果类型:
期刊论文
论文标题(英文):
Research Progress in Species Differences and Underlying Physiological Mechanism of Noise-induced Hearing Loss
作者:
Cui Zhong-Dan;Wu Jing;Tang Jia;Chen Qi-Cai;Fu Zi-Ying
作者机构:
[Wu Jing; Fu Zi-Ying; Chen Qi-Cai; Tang Jia; Cui Zhong-Dan] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan 430079, Peoples R China.
语种:
中文
关键词:
噪声性听力损失;暂时性阈值偏移;永久性阈值偏移;隐性听力损失;毛细胞;物种差异;生理机制
关键词(英文):
noise-induced hearing loss;temporary threshold shift;permanent threshold shift;hidden hearing loss;hair cell;species differences;physiological mechanism
期刊:
生物化学与生物物理进展
ISSN:
1000-3282
年:
2021
卷:
48
期:
4
页码:
407-422
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31200832,31772454]; Hubei Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [2019CFB758]; Fundamental Research Funds for Central UniversitiesFundamental Research Funds for the Central Universities [CCNU20TS018]
机构署名:
本校为第一机构
院系归属:
生命科学学院
摘要:
噪声广泛存在于人和动物的生活环境中,从无脊椎动物到哺乳动物乃至人类,都会受到噪声的负面影响.强烈的噪声会损伤听觉系统的结构和功能,引起噪声性听力损失(noise-induced hearing loss,NIHL).本文对噪声性听力损失的类型、影响因素、噪声所致不同程度听力损失形成的可能机制进行了总结,发现NIHL主要与突触结构肿胀、谷氨酸引起的可逆兴奋性中毒以及活性氧引起的氧化应激、细胞凋亡、带状体损伤、α激动型鸟嘌呤核苷酸结合蛋白(guanine nucleotide binding protein alpha stimulating,GNAS)基因的mRNA及其上游lncRNA Sept7的表达量上调等因素有关.比较噪声暴露后不同物种听力损失情况的差异...
摘要(英文):
Noise widely exists in animals and human everyday life, it has negative influence on animals from invertebrates to mammals, and even human beings. High level noise can cause damage to auditory structure and function, decrease auditory neural sensitivity and behavioral acuity, and even lead to noise-induced hearing loss (NIHL). In this review, we summarized influence impacts and classification of NIHL, and possible mechanisms underlying the NIHL. Previous research on NIHL showed that the NIHL was related to postsynaptic terminals swelling, reversible excitotoxicity induced by glutamate and reac...

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