期刊论文、会议论文

Yang, Guang-Fu

英文

Journal of Molecular Modeling

1610-2940

2011

17

3

495-503

The 5th International Conference of Molecular Simulations and Applied Informatics Technologies(第五届国际分子模拟与信息技术应用学术会议 ICMS&I)

The 5th International Conference of Molecular Simulations and Applied Informatics Technologies(第五届国际分子模拟与信息技术应用学术会议 ICMS&I)论文集

2010-09-01

武汉

中国化学会<&wdkj&>华中师范大学<&wdkj&>创腾科技有限公司<&wdkj&>中科院上海药物研究所

10.1007/s00894-010-0742-4

National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126103]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20925206 20932005, 20902034]

本校为第一且通讯机构

Herbicides targeting grass plastidic acetyl-CoA carboxylase (ACCase, EC 6.4.1.2) are selectively effective against graminicides. The intensive worldwide use of this herbicide family has selected for resistance genes in a number of grass weed species. Recently, the active-site W374C mutation was found to confer multi-drug resistance toward haloxyfop (HF), fenoxaprop (FR), Diclofop (DF), and clodinafop (CF) in A. myosuroides. In order to uncover the resistance mechanism due to W374C mutation, the binding of above-mentioned four herbicides to both...