The authors thank Dr. Yun Zhao and Dr. Yuqing Zhu for the help in building asthma model. This work was supported by the National Key Research and Development Program of China ( 2017YFC0702700 ), the National Natural Science Foundation of China ( 21577045 ), Self-determined Research Funds of CCNU from the colleges’basic research and operation of MOE ( CCNU17ZDJC05 ).
机构署名：
本校为第一且通讯机构
院系归属：
生命科学学院
摘要：
Diisononyl phthalate (DINP) and formaldehyde both are associated with asthma and allergies. However, it is unclear about the adverse effect of DINP and formaldehyde exposure on the brain for asthma patients. Here, we determined the effect of DINP and/or formaldehyde exposure on neuroinflammation in brain by a murine asthma model and investigated the underlying mechanisms. Mice were exposed to formaldehyde and/or DINP and sensitization with ovalbumin. The results show that exposure to formaldehyde and/or DINP not only exacerbated allergic asthma...
