The authors would like to thank the Editor, the Associate Editor, and the two reviewers for their constructive and insightful comments and suggestions that greatly improved the paper. This work is supported by the State Key Program of the National Natural Science Foundation of China (No:12031016), National Natural Science Foundation of China (No:11971324,11971362,11901581,12101256), Natural Science Foundation of Hubei Province (No:2021CFB502), the Interdisciplinary Construction of Bioinformatics and Statistics, and the Academy for Multidisciplinary Studies, Capital Normal University.