Effects of combined exposure to formaldehyde and benzene on immune cells in the blood and spleen in Balb/c mice

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成果类型：

期刊论文

作者：

Wen, Huaxiao;Yuan, Langyue;Wei, Chenxi;Zhao, Yun;Qian, Yan;...

通讯作者：

Yang, Xu;Wang, Xianliang

作者机构：

[Wei, Chenxi; Yuan, Langyue; Wen, Huaxiao; Yang, Xu; Zhao, Yun; Ding, Shumao] Cent China Normal Univ, Sch Life Sci, Lab Environm Biomed, Wuhan, Peoples R China.

[Qian, Yan] Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing, Peoples R China.

[Yang, Xu; Ma, Ping] Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning, Peoples R China.

[Wang, Xianliang] Chinese Ctr Dis Control & Prevent, Inst Environm Hlth & Related Prod Safety, Beijing, Peoples R China.

通讯机构：

[Yang, Xu; Wang, Xianliang] C

[Yang, Xu] H

Cent China Normal Univ, Sch Life Sci, Lab Environm Biomed, Wuhan, Peoples R China.

Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning, Peoples R China.

Chinese Ctr Dis Control & Prevent, Inst Environm Hlth & Related Prod Safety, Beijing, Peoples R China.

语种：

英文

关键词：

Immunotoxicity;Benzene;Formaldehyde;Combined exposure;Blood;Spleen;Oxidative damage

期刊：

Environmental Toxicology and Pharmacology

ISSN：

1382-6689

年：

2016

卷：

页码：

265-273

DOI：

10.1016/j.etap.2016.05.007

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577045, 20907047]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB525005]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Formaldehyde and benzene are the two major indoor air pollutants due to their prevalence and toxicity. This study aimed to explore the toxic effect on the spleen and relevant immune responses of Ball* mice caused by exposure to a combination of formaldehyde and benzene. Balb/c mice were divided randomly into five groups (n = 9/group): blank control group (Ctrl); solvent ([corn] Oil) control; formaldehyde only (FA, 3 mg/m(3)); benzene only (BZ, 150 mg/kg BW); and, formaldehyde +benzene group (FA+ BZ). Exposures were performed for 8 hiday, 5 day/week, for 2 weeks. Tail blood was collected after ...

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Effects of combined exposure to formaldehyde and benzene on immune cells in the blood and spleen in Balb/c mice

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