Formaldehyde-induced paxillin-tyrosine phosphorylation and paxillin and P53 downexpression in Hela cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Yun;Wei, Chenxi;Wu, Yang;Ma, Ping;Ding, Shumao;...

通讯作者：

Yang, Xu;Shen, Dingwen

作者机构：

[Yuan, Junlin; Yang, Xu; Zhao, Yun; Ding, Shumao] Cent China Normal Univ, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Sch Life Sci, Wuhan 430079, Peoples R China.

[Wei, Chenxi] Hunan Normal Univ, Coll Life Sci, Key Lab Ecol Safety Monitoring & Evaluat, Changsha, Hunan, Peoples R China.

[Wu, Yang; Shen, Dingwen; Ma, Ping] Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning 437100, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.

[Shen, Dingwen] Hubei Univ Sci & technol, 88 Xianning Rd, Xianning 437100, Peoples R China.

通讯机构：

[Yang, Xu] C

[Shen, Dingwen] H

Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.

Hubei Univ Sci & technol, 88 Xianning Rd, Xianning 437100, Peoples R China.

语种：

英文

关键词：

Formaldehyde;Hela cell;P53;Western blot;immunofluorescence;paxillin;phosphotyrosine

期刊：

Toxicology Mechanisms and Methods

ISSN：

1537-6516

年：

2016

卷：

期：

页码：

75-81

DOI：

10.3109/15376516.2015.1082001

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51136002]; Hubei Province Natural Science Foundation Project [2014CFB284]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Formaldehyde (FA) is an environmental pollutant and an endogenous product believed to be involved in tumorigenesis. However, the underlying mechanism of observed FA effects has not been clearly defined. Paxillin is a focal adhesion protein that may play an important role in several signaling pathways. Many paxillin-interacting proteins are involved in the regulation of actin cytoskeleton organization, which is necessary for cell motility events associated with diverse biological responses, such as embryonic development, wound repair and tumor m...

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Formaldehyde-induced paxillin-tyrosine phosphorylation and paxillin and P53 downexpression in Hela cells

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