Photoswitchable AIE photosensitizer for reversible control of singlet oxygen generation in specific bacterial discrimination and photocontrolled photodynamic killing of bacteria

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成果类型：

期刊论文

作者：

Li, Ziyong;Chen, Si;Huang, Yurou;Zhou, Hui;Yang, Shuren;...

通讯作者：

Guo, Hui(guohui0319@nankai.edu.cn)

作者机构：

[Li, Ziyong; Guo, Hui; Chen, Si; Wang, Mingxing; Zhou, Hui; Zhang, Haining; Yang, Shuren] Luoyang Normal Univ, Coll Food & Drug, Coll Chem & Chem Engn, Luoyang Key Lab Organ Funct Mol, Luoyang 471934, Peoples R China.

[Huang, Yurou; Yin, Jun] Cent China Normal Univ, Minist Educ,Coll Chem,Hubei Int Sci & Technol Coop, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.

通讯机构：

[Hui Guo] L

[Jun Yin] K

Luoyang Key Laboratory of Organic Functional Molecules, College of Food and Drug, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang 471934, PR China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, PR China

语种：

英文

关键词：

Aggregation-induced emission (AIE);Dithienylethene;Photochromism;Photodynamic therapy (PDT);Photosensitizer;Singlet oxygen

期刊：

Chemical Engineering Journal

ISSN：

1385-8947

年：

2022

卷：

450

页码：

138087

DOI：

10.1016/j.cej.2022.138087

基金类别：

The authors acknowledge financial support from Natural Science Foundation of Henan Province (No. 222300420501 ), the Science and Technology Project of Henan Province (No. 212102210549 ), and the Key Scientific Research Project of Higher Education of Henan Province (No. 22A430007 ), and National College Students Innovation and Entrepreneurship Training Program (No. 202210482028 ).

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本校为其他机构

院系归属：

化学学院

摘要：

The photosensitizer system that allows for reversible noninvasive control over singlet oxygen generation (1O2) is in great demand for precise photodynamic therapy (PDT) aimed at reducing non-specific damage to the normal cells or tissues. However, they often suffer from fluorescence quenching and insufficient 1O2 generation due to aggregation-caused quenching (ACQ) phenomenon in a hydrophilic and physiological environment, severely limiting their applications in both imaging and PDT therapy. Herein, a novel positively charged photoswitchable ph...

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Photoswitchable AIE photosensitizer for reversible control of singlet oxygen generation in specific bacterial discrimination and photocontrolled photodynamic killing of bacteria

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