期刊论文

Liu, Kaiyu

英文

TOXINS

2072-6651

2020

12

6

375-

10.3390/toxins12060375

Conceptualization, K.L. and A.B.; Formal analysis, J.Z., M.J., Y.Y. (Yanchao Yang), Y.X., L.L., I.G., and M.S.; Funding acquisition, K.L.; Investigation, J.Z., M.J., Y.Y. (Yangchao Yang), and Y.Y. (Yongbo Yang); Writing original draft, J.Z. and M.J.; Writing review and editing, K.L., A.B., and M.S.; Supervision, K.L. All authors have read and agreed to the published version of the manuscript. This work was supported by the National Key R&D Program of China (grant number: 2017YFD0200400).

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It is well known that insect larval midgut cadherin protein serves as a receptor of Bacillus thuringiensis (Bt) crystal Cry1Ac or Cry1Ab toxins, since structural mutations and downregulation of cad gene expression are linked with resistance to Cry1Ac toxin in several lepidopteran insects. However, the role of Spodoptera frugiperda cadherin protein (SfCad) in the mode of action of Bt toxins remains elusive. Here, we investigated whether SfCad is involved in susceptibility to Cry1Ab or Cry1Fa toxins. In vivo, knockout of the SfCad gene by CRISPR/...