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Iodine-Promoted Oxidative Cyclization of Methyl Azaarenes and α‑Amino Ketones for One-Pot Synthesis of 2‑Azaaryl-5-aryl Oxazoles

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成果类型:
期刊论文
作者:
Zhu, Yan-Ping;Zhou, Yu;Li, Wen-Juan;Liu, Fu-Rao;Wang, R. China Wen-Cheng;...
通讯作者:
Yan-Ping Zhu
作者机构:
[Liu, Fu-Rao; Li, Wen-Juan; Zhou, Yu; Chao, Bing-Yu; Hao, Kai-Yan; Wang, R. China Wen-Cheng; Sun, Yun-Yuan; Zhu, Yan-Ping; Shi, Tian-Ru] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm,Minist Educ, Yantai 264005, Shandong, Peoples R China.
[Wu, An-Xin] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Yan-Ping Zhu] S
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Shandong Yantai, 264005, P. R. China
语种:
英文
期刊:
JOURNAL OF ORGANIC CHEMISTRY
ISSN:
0022-3263
年:
2022
卷:
87
期:
18
页码:
12460-12469
基金类别:
Science and Technology Innovation Development Plan of Yantai [2020MSGY114]; Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
A high efficiency protocol was developed for the synthesis of 2,5-disubstituted oxazoles via iodine-promoted oxidative domino cyclization. These reactions were performed with readily available methyl azaarenes and α-amino ketones under metal-free conditions. This protocol is a simple method with high functional group compatibility, a wide range of substrates, and excellent yield, providing a...

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