期刊论文

Lu, Liang-Qiu;Xiao, Wen-Jing;Lan, Yu

英文

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1433-7851

2019

58

32

11013-11017

10.1002/anie.201905993

We are grateful to the National Science Foundation of China (No. 21822103, 21820102003, 21822303, 21772052, 21772053, 21572074 and 21472057), the Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019), the Natural Science Foundation of Hubei Province (2017AHB047), the Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province (2016kf03), and the International Joint Research Center for Intelligent Biosensing Technology and Health for support of this research.

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Catalytic asymmetric cycloadditions of ambident Pd-containing dipolar species with nucleophilic dipolarophiles, namely, inverse-electron-demand cycloadditions, are challenging and underdeveloped. Possibly, the inherent linear selectivity of Pd-catalyzed intermolecular allylations and the lack of efficient chiral ligands are responsible for this limitation. Herein, two cycloadditions of such intermediates with deconjugated butenolides and azlactones were accomplished by using a novel chiral hybrid P,S-ligand and hydrogen bonding. By doing so, hi...