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Low concentrations of FA exhibits the Hormesis effect by affecting cell division and the Warburg effect

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成果类型:
期刊论文
作者:
An, Jieran;Li, Fuhong;Qin, Yujie;Zhang, Hongmao;Ding, Shumao*
通讯作者:
Ding, Shumao
作者机构:
[Qin, Yujie; An, Jieran; Zhang, Hongmao; Li, Fuhong; Ding, Shumao] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.
[An, Jieran] China Agr Univ, Key Lab Funct Dairy Coconstructed Minist Educ & B, Beijing, Peoples R China.
[Ding, Shumao] Cent China Normal Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China.
通讯机构:
[Ding, Shumao] C
Cent China Normal Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China.
语种:
英文
关键词:
Cell division;Cell proliferation;Formaldehyde (FA);The Hormesis effect;The Warburg effect
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2019
卷:
183
页码:
109576
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772471]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Formaldehyde (FA), a ubiquitous indoor environmental pollutant, has been classified as a carcinogen. There are many studies showed that low levels of FA could promote cell proliferation, however, little is known about the signal pathways. To determine the potential molecular mechanisms, human chronic myeloid leukemia cells (K562 cells) and human bronchial epithelial cells (16HBE cells) were exposed to different concentrations of FA. The data showed that FA at 0–125 μM or 0–60 μM promoted the proliferation of K562 cells or 16HBE cells respec...

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