Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s disease mice model

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成果类型：

期刊论文

作者：

Shen, Zhuping;Huang, Jiawei;Wei, Hui;Niu, Huan;Li, Bitong;...

通讯作者：

Liu, Guozhen

作者机构：

[Shen, Zhuping; Liu, Guozhen; Wei, Hui] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.

[Li, Rui; Huang, Jiawei] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Niu, Huan; Li, Bitong; Liu, Guozhen] Univ New South Wales, Fac Engn, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia.

[Liu, Guozhen] Univ New South Wales, Australian Ctr NanoMed, Sydney, NSW 2052, Australia.

[Liu, Guozhen] Univ New South Wales, Grad Sch Biomed Engn, Sydney, NSW, Australia.

通讯机构：

[Liu, Guozhen] U

Univ New South Wales, Grad Sch Biomed Engn, Sydney, NSW, Australia.

语种：

英文

关键词：

Cytokines;Electrochemical immunosensors;Multiplex sensing;In vivo detection;Parkinson's disease;Mouse brain

期刊：

Bioelectrochemistry

ISSN：

1567-5394

年：

2020

卷：

134

页码：

107532

DOI：

10.1016/j.bioelechem.2020.107532

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21575045]; Australian Research Council Future FellowshipAustralian Research Council [FT160100039]; UNSW Biomedical Engineering Seed Fund; UNSW Digital Grid Futures Institute Seed Fund; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU18JCXK07]

机构署名：

本校为第一机构

院系归属：

生命科学学院

摘要：

Parkinson's Disease (PD) is a neurodegenerative chronic disorder which destroys brain tissue and result in impaired movement. Early diagnosis of PD before the appearance of clinical symptom is vital for effective treatment. High levels of proinflammatory cytokines found in PD patient's brains, as natural inflammation response product, are potential biomarkers for PD detection in the early stage. Herein, we developed an in vivo electrochemical immunosensing device based on glassy carbon rod to simultaneously detect three proinflammatory cytokine...

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Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s disease mice model

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