Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice

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成果类型：

期刊论文

作者：

Ge, Jing;Yang, Honglian;Lu, Xianxian;Wang, Shenqi;Zhao, Yun;...

通讯作者：

Li, Rui;Zhang, Luoping

作者机构：

[Li, Rui; Zhao, Yun; Huang, Jiawei; Lu, Xianxian; Ge, Jing] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Zhang, Luoping] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.

[Xi, Zhuge; Yang, Honglian] Tianjin Inst Environm & Operat Med, Tianjin 300050, Peoples R China.

[Wang, Shenqi; Ge, Jing] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China.

通讯机构：

[Li, Rui] C

[Zhang, Luoping] U

Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.

语种：

英文

关键词：

PM2.5;Formaldehyde;Combined exposure;Hematopoietic toxicity;Molecular mechanism

期刊：

Environment International

ISSN：

0160-4120

年：

2020

卷：

144

页码：

106050

DOI：

10.1016/j.envint.2020.106050

基金类别：

National Key Research and Development Program of China [2017YFC0702700]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU18JCXK07, CCNU19TS066]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

PM2.5 and formaldehyde (FA) are major outdoor and indoor air pollutants in China, respectively, and both are known to be harmful to human health and to be carcinogenic. Of all the known chronic health effects, leukaemia is one of the most serious health risks associated with these two pollutants. To explore the influence and underlying mechanisms of exposure to formaldehyde and PM2.5 on hematopoietic toxicity, we systematically studied the toxicity induced in hematopoietic organs: bone marrow (BM); spleen; and myeloid progenitor cells (MPCs). M...

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Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice

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