期刊论文

Study on Biologically Active Organophospborus CompoundsⅧ.Synthesis and Properties of 4-(quinoxalyl-2-oxy)phenyl Alkyl N-alkyl Phosphoramidothioates

中文

合成化学

1005-1511

1994

03

251-257

10.15952/j.cnki.cjsc.1994.03.010

本校为第一机构

以烷基硫代磷酰二氯为磷酰化试剂，先后分别与４－（喹喔啉－２－氧代）苯酚和相应的取代胺或醇进行磷酰化反应，合成了８个未见文献报道的标题化合物Ⅱａ～ｈ，它们的结构经元素分析，ＩＲ，￣１Ｈ－ＮＭＲ，￣（３１）Ｐ－ＮＭＲ和ＭＳ所证实，并初步研究了它们的波谱性质。

Synthesis of eight new title compounds Ⅱa～h is described.Ⅱa～g were synthesizedby the nucleophilic displacement of alkyl phosphoredichloridothionate by sedium 4-(quinoxalyl-2-oxy)phenolate followed by secondary amines in polar organic solvent under mild conditions,Ⅱh was syn-thesized by the base-catalyzed phosphorylation of 4-(quinoxalyl-2-oxy)phenol using diethyl phospho-rochloridothionate as phosphorylating agent in nonprotonic solvent.The strucrure of all new com-pounds was conf...