期刊论文

Wang, Xin

中文

生理学报

0371-0874

2018

70

2

132-140

10.13294/j.aps.2018.0028

supported by the National Natural Science Foundation of China（No.31000493） the Natural Science Foundation of Hubei Province,China（No.2014CFB655） the Scientific Research Project Fund for Youth Teachers from Central China Normal University（No.CCNU15A05035） the Fund of Hubei Key Laboratory of Genetic Regulation and Integrative Biology,China（No.GRIB201508）

本校为第一且通讯机构

听觉系统具备随着环境的变化来改变自身结构和功能的能力,这种能力称为听觉可塑性。中脑下丘(inferior colliculus, IC)是听觉系统重要的中继站,外侧丘系背核(dorsal nuclei of lateral lemniscus, DNLL)上行输入对IC神经元的声反应特性具有重要的定型作用。本研究旨在探讨DNLL上行输入在IC神经元可塑性形成中的作用。以昆明小鼠为实验动物,持续电刺激对侧DNLL,采用单单位细胞外记录的方法观察IC神经元的可塑性变化。结果显示,95%的受抑制IC神经元和86%的受易化IC神经元在对侧DNLL 30 min电刺激停止后仍表现出可塑性的变化。在对侧DNLL电刺激停止1 h后,74%的受抑制IC神经元发生的可塑性变化消失...

The auditory system has the ability to adjust its structure and function as the environment changes, which is called auditory plasticity. In the auditory system, inferior colliculus (IC) is an important relay station, which accepts the ascending inputs from dorsal nuclei of lateral lemniscus (DNLL). The present study was aimed to investigate the role of the DNLL in the formation of the plasticity of IC neurons. Here, we used extracellular single unit recording and electrical stimulation to investigate the plasticity of IC neurons in Kunming mice. The results showed that after the cessation of ...