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Temperature‐Controlled Base‐Promoted Cyclization for the Synthesis of 2‐Amino‐4H‐benzo[d][1,3]thiazin‐4‐ones and 2‐Thioxo‐4(3H)‐quinazolinones

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成果类型:
期刊论文
作者:
Zhou, Zhi-Wen;Jia, Feng-Cheng;Xu, Cheng;Jiang, Shi-Fen;Wu, Yan-Dong;...
通讯作者:
Wu, An-Xin(吴安心
作者机构:
[Wu, An-Xin; Jia, Feng-Cheng; Zhou, Zhi-Wen; Xu, Cheng; Jiang, Shi-Fen; Wu, Yan-Dong] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, An-Xin] C
Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
2-thioxo-4(3 h)-quinazolinone;4h-benzo[d][1,3]thiazin-4-one;chemoselective;isatin;isothiocyanate
期刊:
Asian Journal of Organic Chemistry
ISSN:
2193-5807
年:
2017
卷:
6
期:
12
页码:
1773-1777
基金类别:
We are grateful to the National Natural Science Foundation of China (Grants 21602070 and 21472056) and the Fundamental Research Funds for the Central Universities (CCNU15ZX002 and CCNU16A05002) for financial support. We acknowledge the graduate student educational innovation grant from Central China Normal University (2016CXZZ67). This work was also supported by the 111 Project B17019.
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A base-promoted and highly selective temperature-dependent tandem oxidation/decarboxylative cyclization of isothiocyanates and isatins has been developed. This method allows the chemodivergent synthesis of 4H-benzo[d][1,3]thiazin-4-ones and 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones in moderate to high yields. © 2017 Wi...

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