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β-Cyclodextrin-Self-Assembled Nanochannel Membrane for the Separation of Chiral Drugs

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成果类型:
期刊论文
作者:
Zhang, Siyun;Chen, Xue;Sun, Lingda;Li, Haibing*
通讯作者:
Li, Haibing
作者机构:
[Li, Haibing; Sun, Lingda; Zhang, Siyun; Chen, Xue] Cent China Normal Univ CCNU, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ MOE, Wuhan 430079, Peoples R China.
通讯机构:
[Li, Haibing] C
Cent China Normal Univ CCNU, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ MOE, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
chiral drugs;host-guest chemistry;nanochannel membrane;separation;β-cyclodextrin
期刊:
ACS Applied Nano Materials
ISSN:
2574-0970
年:
2020
卷:
3
期:
5
页码:
4351-4356
基金类别:
National Key Research and Development Program of China [2018YFD0200102]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21911530178, 21772055, 21572076]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; self-determined research funds of CCNU from the colleges' basic research and operation of MOE
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
The fabrication of a membrane with the capability of chiral selective transport is a big challenge in the membrane separation of chiral drugs. To solve the problem of chiral selectivity in membrane separation, drug/metabolite transport (DMT) in the cell membrane inspires a bionic strategy based on the nanochannel membrane. Herein, the DMT-inspired nanochannel membrane is fabricated by the self-assembly of cyclodextrin (CD) in nanochannels and used for the chiral transport and separation of model chiral drugs such as naproxen (NAP). As a result,...

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