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Studies of O,O-Dimethyl alpha-(2,4-Dichlorophenoxyacetoxy)ethylphosphonate (HW02) as a New Herbicide. 1. Synthesis and Herbicidal Activity of HW02 and Analogues as Novel Inhibitors of Pyruvate Dehydrogenase Complex

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成果类型:
期刊论文
作者:
He, Hong-Wu*;Yuan, Jun-Lin;Peng, Hao;Chen, Ting;Shen, Ping;...
通讯作者:
He, Hong-Wu
作者机构:
[Tan, Hong-Liang; Peng, Hao; He, Jun-Bo; He, Hong-Wu; He, Ya-Hui; Li, Yan; Chen, Ting; Li, Yanjun; Shen, Ping; Wan, Shu-Qing; Yuan, Jun-Lin] Cent China Normal Univ, Coll Chem, Inst Pesticide Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[He, Hong-Wu] C
Cent China Normal Univ, Coll Chem, Inst Pesticide Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
alpha-(substituted phenoxyacetoxy)alkylphosphonate;herbicidal activity;pyruvate dehydrogenase complex;inhibitor;structure-activity relationships
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2011
卷:
59
期:
9
页码:
4801-4813
基金类别:
National Basic Research Program of ChinaNational Basic Research Program of China [2003CB114400, 2010CB126100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20372023, 20772042, 21002037]; PCSIRTProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT0953]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitor...

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