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HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules

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成果类型:
期刊论文
作者:
Khatkar, Pooja;Mensah, Gifty;Ning, Shangbo;Cowen, Maria;Kim, Yuriy;...
通讯作者:
Kashanchi, F
作者机构:
[Mensah, Gifty; Khatkar, Pooja; Kim, Yuriy; Kashanchi, Fatah; Cowen, Maria; Williams, Anastasia] George Mason Univ, Sch Syst Biol, Lab Mol Virol, Manassas, VA 20110 USA.
[Ning, Shangbo; Zhao, Yunjie] Cent China Normal Univ, Inst Biophys, Dept Phys, Wuhan 430079, Peoples R China.
[Le Grice, Stuart F. J.; Abulwerdi, Fardokht A.] NCI, Basic Res Lab, Frederick, MD 21702 USA.
[Zeng, Chen] George Washington Univ, Phys Dept, Washington, DC 20052 USA.
通讯机构:
[Kashanchi, F ] G
George Mason Univ, Sch Syst Biol, Lab Mol Virol, Manassas, VA 20110 USA.
语种:
英文
关键词:
HIV-1 transcription;transactivation response element (TAR) RNA;transcription elongation factor-b (P-TEFb);SWI/SNF complex;molecular modeling;molecular simulation
期刊:
Pharmaceuticals
ISSN:
1424-8247
年:
2024
卷:
17
期:
1
页码:
33-
基金类别:
Conceptualization, P.K., S.F.J.L.G. and F.K.; methodology, P.K., S.N., Y.Z., F.A.A., C.Z., G.M., Y.K., M.C., Y.Z., A.W., S.F.J.L.G. and F.K.; software, P.K., S.N., Y.K., Y.Z. and C.Z.; validation, P.K., Y.Z. and C.Z.; formal analysis, P.K., Y.Z. and F.K.; investigation, F.K. and P.K.; resources, F.K., Y.Z., F.A.A. and S.F.J.L.G.; data curation, P.K. and F.K.; writing—P.K.; editing—P.K. and F.K.; visualization, P.K., S.N., C.Z. and F.K.; supervision, F.K.; project administration, F.K.; funding acquisition, F.K. and Y.Z. All authors have read and agreed to the published version of the manuscript. This work was supported by “Targeted Pharmaceuticals (GMU#223390)” and “National Institutes of Health (NIH) Grants (AI078859, AI074410, AI127351-01, AI043894, NS099029, and DA050176)” to F.K., and the “National Natural Science Foundation of China (grant No. 12175081) and Fundamental Research Funds for the Central Universities (grant No. CCNU22QN004)” to Yunjie.
机构署名:
本校为其他机构
院系归属:
物理科学与技术学院
心理学院
摘要:
The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat-TAR interaction, unique to the virus, is a promising target for developing antiviral therapeutics. Currently, there are no FDA-approved drugs against HIV-1 transcription, suggesting the need to develop novel inhibitors that specifically target HIV-1 transcription. We have identified potential candidates that ef...

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