Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling

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成果类型：

期刊论文

作者：

Wang, Zhaowei;Wu, Di;Liu, Yongxiang;Xia, Xiaoling;Gong, Wanyun;...

通讯作者：

Zhou, Xi

作者机构：

[Liu, Yongxiang; Gong, Wanyun; Wang, Zhaowei; Wu, Di; Qiu, Yang; Zhou, Xi; Yang, Jie; Hu, Yuanyang; Xia, Xiaoling] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China.

[Li, Jingjing; Wang, Yu-Feng; Zheng, Ya] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

[Xiang, Ye] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China.

通讯机构：

[Zhou, Xi] W

Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China.

语种：

英文

关键词：

Dicer-2;RNA silencing;Toll signaling;invertebrate immunity;posttranscriptional gene regulation

期刊：

Science Advances

ISSN：

2375-2548

年：

2015

卷：

期：

页码：

e1500228

DOI：

10.1126/sciadv.1500228

基金类别：

National High-Tech R&D Program of China (863 Program)National High Technology Research and Development Program of China [2015AA020939]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2014CB542603]; National Natural Science Foundation Excellent Young Scientists Fund [31522004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270190, 81201292]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [204274386]; Chinese 111 ProjectMinistry of Education, China - 111 Project [B06018]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Dicer-2 is the central player for small interfering RNA biogenesis in the Drosophila RNA interference (RNAi) pathway. Intriguingly, we found that Dicer-2 has an unconventional RNAi-independent function that positively modulates Toll immune signaling, which defends against Gram-positive bacteria, fungi, and some viruses, in both cells and adult flies. The loss of Dicer-2 expression makes fruit flies more susceptible to fungal infection. We further revealed that Dicer-2 posttranscriptionally modulates Toll signaling because Dicer-2 is required fo...

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Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling

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