Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

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成果类型：

期刊论文

作者：

Chen, Zhian;Cui, Yanfang;Yao, Yin;Liu, Bo;Yunis, Joseph;...

通讯作者：

Di Yu

作者机构：

[Canete, Pablo F.; Wang, Runli; Yao, Yin; Yunis, Joseph; Chen, Zhian; Wang, Naiqi; Davis, David Simon; Yu, Di; Yu, Zhijia; Wang, Hao] Univ Queensland, Frazer Inst, Fac Med, Brisbane, Qld, Australia.

[Wang, Runli; Yao, Yin; Yunis, Joseph; Roco, Jonathan A.; Gao, Xin; Chen, Zhian; Davis, David Simon; Yu, Di; Parish, Christopher; Yu, Zhijia; Wang, Hao] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT, Australia.

[Cui, Yanfang] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.

[Yao, Yin; Liu, Zheng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhan, Peoples R China.

[Qi, Hai; Liu, Bo] Tsinghua Univ, Tsinghua Peking Ctr Life Sci, Sch Med cine, Lab Dynam Immunobiol, Beijing, Peoples R China.

通讯机构：

[Di Yu] F

Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.<&wdkj&>John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.<&wdkj&>Ian Frazer Centre for Children’s Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.

语种：

英文

期刊：

SCIENCE IMMUNOLOGY

ISSN：

2470-9468

年：

2023

卷：

期：

DOI：

10.1126/sciimmunol.add1728

基金类别：

Flow Cytometry Facility of John Curtin School of Medical Research [QLD 4102]; Australian Government; Australian National Health and Medical Research Council [GNT1085509, GNT1147769, GNT2009554]; National Natural Science Foundation of China [21473065]

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院系归属：

化学学院

摘要：

In antibody responses, mutated germinal center B (BGc) cells are positively selected for reentry or differentiation. As the products from GCs, memory B cells and antibody-secreting cells (ASCs) support high-affinity and long-lasting immunity. Positive selection of BGc cells is controlled by signals received through the B cell receptor (BCR) and follicular helper T (TFH) cell -derived signals, in particular costimulation through CD40. Here, we demon-strate that the TFH cell effector cytokine interleukin-21 (IL-21) joins BCR and CD40 in supporting BOc selection and reveal that strong IL-21 signa...

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Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

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