pH-responsive allochroic nanoparticles for the multicolor detection of breast cancer biomarkers.

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成果类型：

期刊论文

作者：

Xu, Weiqing;Jiao, Lei;Ye, Huarong;Guo, Zhenzhong;Wu, Yu;...

通讯作者：

Zhu, Chengzhou

作者机构：

[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.

[Ye, Huarong] China Resources & Wisco Gen Hosp, Wuhan 430080, Hubei, Peoples R China.

[Guo, Zhenzhong] Wuhan Univ Sci & Technol, Med Coll, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Hubei, Peoples R China.

[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.

通讯机构：

[Zhu, Chengzhou] C

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

Breast cancer biomarkers;Colorimetric detection;Enzyme-linked immunosorbent assay;Self-assembly;Smartphones;pH indicators

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2020

卷：

148

页码：

111780

DOI：

10.1016/j.bios.2019.111780

基金类别：

CRediT authorship contribution statement Weiqing Xu: Investigation, Data curation, Writing - original draft. Lei Jiao: Investigation, Data curation, Writing - original draft. Huarong Ye: Resources. Zhenzhong Guo: Resources. Yu Wu: Visualization. Hongye Yan: Writing - review & editing. Wenling Gu: Writing - review & editing. Dan Du: Writing - review & editing. Yuehe Lin: Writing - review & editing. Chengzhou Zhu: Conceptualization, Methodology, acquisition, Writing - review & editing, Project administration.

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) are the three crucial biomarkers for the clinical diagnosis of breast cancer. Sensitive and precise detection of ER, PR, and HER2 is of great significance for the diagnosis of breast cancer. Herein, through a simple solvent-induced self-assembly process, the self-carried allochroic nanoparticles were prepared by using some hydrophobic pH indicator molecules for allochroic NPs-linked immunosorbent assay (named ALISA) of ER, PR, and HER2, respe...

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pH-responsive allochroic nanoparticles for the multicolor detection of breast cancer biomarkers.

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