A protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern

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成果类型：

期刊论文

作者：

Zhang, Ru-Yan;Yin, Xu-Guang;Zhou, Shi-Hao;Zhang, Hai-Wei;Lu, Jie;...

通讯作者：

Yang, Guang-Fu;Guo, J;Gong, R

作者机构：

[Wang, Jian; Liu, Yan-Ling; Feng, Ran-Ran; Wen, Yu; Yin, Xu-Guang; He, Chen-Bin; Zhou, Shi-Hao; Li, Yu-Ting; Yang, Guang-Fu; Zhang, Ru-Yan; Lu, Jie; Ding, Dong; Guo, J; Guo, Jun] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.

[Gong, Rui; Zhang, Hai-Wei; Gong, R] Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China.

[Wei, Hua-Wei] Jiangsu East Mab Biomed Technol Co Ltd, Nantong 226499, Peoples R China.

通讯机构：

[Guo, J ; Yang, GF; Gong, R ] C

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.

Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China.

语种：

英文

期刊：

Chemical Communications

ISSN：

1359-7345

年：

2022

卷：

期：

页码：

3925-3928

DOI：

10.1039/d2cc00271j

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [22177035, 21772056]; National Key Research and Development Program of China [2017YFA 0505200]; Wuhan Bureau of Science and Technology [2020 020601012217, 2020020101010001]; self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU20TS016]; Program of Introducing Talents of Discipline to Universities of China (111 program) [B17019]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Adjuvants are important components in vaccines to increase the immunogenicity of proteins and induce optimal immunity. In this study, we designed a novel ternary adjuvant system Alum + c-GAMP + poly(I:C) with STING agonist 3,3′-c-GAMP (c-GAMP) and TLR3 agonist poly(I:C) co-adsorbed on the conventional adjuvant aluminum gel (Alum), and further constructed an S1 protein vaccine. Two doses of vaccination with the ternary adjuvant vaccine were sufficient to induce a balanced Th1/Th2 immune response and robust humoral and cellular immunity. Additio...

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A protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern

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