期刊论文

Shi, YQ;Wang, HJ

英文

Reproductive Toxicology

0890-6238

2024

125

108554

10.1016/j.reprotox.2024.108554

Natural Science Foundation of Hubei Province (CN) [2018CFB638]; Wuhan Preventive Medicine Research Special Project [WY22M01]; Public Health Leading Talents Project of Hubei Province [2021-73]; Hubei Province Key Laboratory of Occupational Hazard Identification and Control [OHIC2021G10]; Excellent Youth Foundation of Hubei Scientific Committee [2018CFA040]; Excellent Young and Middle-aged Scientific Research and Innovation Team Fund, Hubei Provincial Department of Education [T2020003]; 14th Five Year Plan Hubei Provincial advantaged characteristic disciplines (groups) project of Wuhan University of Sci- ence and Technology [2023C0101]

本校为其他机构

Cadmium (Cd) is a harmful environmental pollutant that disrupts public health, including respiratory, digestive, and reproductive systems. In this study, male rats were exposed to CdCl(2) at a dose of 3mg/kg by oral for 28 days to investigate the impact on spermatogenesis. Testis tissue samples were collected after sacrifice, and piRNA expression levels were measured using piRNA microarray and qPCR. PiRNAs, specialized molecules involved in spermatogenesis, were examined. CdCl(2) exposure led to disrupted piRNA expression, particularly in piRNA-DQ759395 in rats. This piRNA was found to have a ...