Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

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成果类型：

期刊论文

作者：

Liu, Ming;Yu, Caixia;Zhang, Zhichao;Song, Mingjing;Sun, Xiuping;...

通讯作者：

Bing Zhang<&wdkj&>Zhibin Zhang

作者机构：

[Liu, Ming; Li, Hongjun; Wan, Xinru; Zhang, Zhibin; Li, Guoliang] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China.

[Liu, Ming; Zhang, Zhibin] Int Soc Zool Sci, Beijing, Peoples R China.

[Liu, Ming; Wang, Yan-Ling] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing, Peoples R China.

[Zhang, Bing; Du, Zhenglin; Yu, Caixia] Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China.

[Zhang, Bing; Du, Zhenglin; Yu, Caixia] China Natl Ctr Bioinformat, Beijing, Peoples R China.

通讯机构：

[Bing Zhang] B

[Zhibin Zhang] S

Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China<&wdkj&>State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China<&wdkj&>International Society of Zoological Sciences, Beijing, China<&wdkj&>CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, China

语种：

英文

关键词：

Mus musculus;Domestication;Positively selected gene;Genome sequencing;Alternative splicing

期刊：

Genome Biology

ISSN：

1474-760X

年：

2022

卷：

期：

页码：

1-23

DOI：

10.1186/s13059-022-02772-1

基金类别：

The study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences (XDB11050300, XDPB16), Key Program of National Natural Science Foundation of China (31330013), External Cooperation Program of Chinese Academy of Sciences (152111KYSB20150023, 152111KYSB20160089) to ZZ (Zhibin Zhang), a grant from the State Key Laboratory of Integrated Management of Pest Insects and Rodents (Chinese IPM1615) to MS, Czech Science Foundation grant (16-23773S) by the Czech Academy of Sciences under the Strategy AV 21 program to JP, and CAS Key Technology Talent Program to BZ.

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic mechanism of laboratory mouse domestication remains unknown due to lack of adequate genomic sequences of wild mice. We analyze the genetic relationships by whole-genome resequencing of 36 wild mice and 36 inbred strains. All classical inbred mice cluster together distinctly from wild and wild-derived inbred mice. Using nucleotide diversity analys...

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Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

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