Monitoring the Dynamic Regulation of the Mitochondrial GTP-to-GDP Ratio with a Genetically Encoded Fluorescent Biosensor

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成果类型：

期刊论文

作者：

Zhang, Meiqi;Yang, Bo;Zhang, Jiayuan;Song, Yuxin;Wang, Weibo;...

通讯作者：

Wang, Jing(wangjingsioc@pku.edu.cn)

作者机构：

[Song, Yuxin; Zhang, Meiqi; Wang, Weibo; Yang, Bo; Li, Na; Wang, Yuan; Li, Wenzhe; Zhang, Jiayuan; Wang, Jing] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.

[Song, Yuxin; Zhang, Meiqi; Wang, Weibo; Yang, Bo; Li, Na; Wang, Yuan; Li, Wenzhe; Zhang, Jiayuan; Wang, Jing] Peking Univ, Dept Chem Biol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China.

[Zhang, Jiayuan] Univ Oxford, Wellcome Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.

[Wang, Weibo] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.

通讯机构：

[Prof. Jing Wang] S

State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical Biology, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Peking University, Beijing, 100191 China

语种：

英文

关键词：

Biosensor;GTP:GDP Ratio;Imaging;Metabolism;Mitochondria

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN：

1433-7851

年：

2022

卷：

期：

页码：

e202201266-

DOI：

10.1002/anie.202201266

基金类别：

This work supported by the National Basic Research Foundation of China (No. 2017YFA0505202 to J. W.), the National Natural Science Foundation of China (No. 91853107 to J. W., No. 21907001 to N. L.). J. W. also thanks the Youth Thousand‐Talents Program of China for support. The authors thank Large‐scale Instrument Platform of State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University for instrument and technical support.

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本校为其他机构

院系归属：

化学学院

摘要：

The interconversion of guanosine triphosphate (GTP) and guanosine diphosphate (GDP) is known to be integral to a wide variety of biological cellular activities, yet to date there are no analytical methods available to directly detect the ratio of intracellular GTP to GDP. Herein, we report GRISerHR, a genetically encoded fluorescent biosensor to monitor the GTP : GDP ratio in multiple cell types and in various organelles under metabolic perturbation. Additionally, we characterized the differential mitochondrial GTP : GDP ratios resulting from g...

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Monitoring the Dynamic Regulation of the Mitochondrial GTP-to-GDP Ratio with a Genetically Encoded Fluorescent Biosensor

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