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Visual and photoelectrochemical analysis of antibiotic resistance genes enabled by surface-engineered ZIF-8@Au cascade nanozymes

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成果类型:
期刊论文
作者:
Yao, Qingfeng;Liu, Lijuan;Cai, Zheng;Meng, Mingxia;Luo, Shuyue;...
通讯作者:
Gong, JM
作者机构:
[Liu, Lijuan; Gong, JM; Meng, Mingxia; Gong, Jingming; Yao, Qingfeng; Cai, Zheng; Luo, Shuyue] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Gong, JM ] C
Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
ARGs;Dual-mode readout;Nanozymes;Visual/PEC assay;ZIF-8@Au
期刊:
Biosensors and Bioelectronics
ISSN:
0956-5663
年:
2024
卷:
261
页码:
116470
基金类别:
CRediT authorship contribution statement Qingfeng Yao: Writing – original draft, Formal analysis, Data curation. Lijuan Liu: Methodology, Formal analysis. Zheng Cai: Visualization, Methodology. Mingxia Meng: Visualization, Methodology. Shuyue Luo: Formal analysis. Jingming Gong: Writing – review & editing, Validation, Supervision, Resources, Project administration, acquisition.
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
The aggravation of antibiotic resistance genes (ARGs) in the environment has posed a significant global health crisis. Accurate evaluation of ARGs levels in a facile manner is a pressing issue for environmental surveillance. Here, we demonstrate a unique dumbbell-shaped cascade nanozyme for visual/photoelectrochemical (PEC) dual-mode detection of ARGs. Gold nanoparticles (AuNPs) with tunable exposed facets are controllably anchored onto ZIF-8 dodecahedrons, exhibiting glucose oxidase (GOx)-like (ZIF-8@Au/G) and peroxidase (POD)-like (ZIF-8@Au/P) activities. Upon the occurrence of ARGs, an asym...

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