Formaldehyde and co-exposure with benzene induce compensation of bone marrow and hematopoietic stem/progenitor cells in BALB/c mice during post-exposure period

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Chenxi;Chen, Mouying;You, Huihui;Qiu, Feng;Wen, Huaxiao;...

通讯作者：

Xiang, Shuanglin;Yang, Xu

作者机构：

[Chen, Mouying; Wei, Chenxi; Qiu, Feng; Xiang, Shuanglin] Hunan Normal Univ, Sch Life Sci, Key Lab Ecol Safety Monitoring & Evaluat, Changsha 410081, Hunan, Peoples R China.

[Wei, Chenxi; Yuan, Junlin; You, Huihui; Wen, Huaxiao; Yang, Xu] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan 430079, Hubei, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Sch Life Sci, 152 Luo Yu Rd, Wuhan 430079, Hubei, Peoples R China.

[Xiang, Shuanglin] Hunan Normal Univ, Sch Life Sci, 36 Lu Shan Rd, Changsha 410081, Hunan, Peoples R China.

通讯机构：

[Xiang, Shuanglin] H

[Yang, Xu] C

Hunan Normal Univ, Sch Life Sci, 36 Lu Shan Rd, Changsha 410081, Hunan, Peoples R China.

Cent China Normal Univ, Sch Life Sci, 152 Luo Yu Rd, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

*Benzene;*Bone marrow;*Formaldehyde;*Hematotoxicity;*Myeloid progenitor;*Post-exposure

期刊：

Toxicology and Applied Pharmacology

ISSN：

0041-008X

年：

2017

卷：

324

期：

页码：

36-44

DOI：

10.1016/j.taap.2017.03.024

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577045]; Doctoral Scientific Research Startup Foundation; Youth Science Foundation of Hunan Normal University [31401]; Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province [20134486]; Hunan Provincial Construct Program of the Key Discipline in Ecology [0713]

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

Formaldehyde (FA) is a human leukemogen. Since there is a latency period between initial FA exposure and the development of leukemia, the subsequent impact of FA on hematopoietic stem or progenitor cells (HSCs/HPCs) in post-exposure stage is crucial for a deep understanding of FA-induced hematotoxicity. BALB/c mice were exposed to 3 mg/m(3) FA for 2 weeks, mimicking occupational exposure, and were monitored for another 7 days post-exposure. Meanwhile, we included benzene (BZ) as a positive control, separately and together with FA because co-exposure occurs frequently. After 7-day recovery, col...

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Formaldehyde and co-exposure with benzene induce compensation of bone marrow and hematopoietic stem/progenitor cells in BALB/c mice during post-exposure period

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