UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development

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成果类型：

期刊论文

作者：

Zhang, Ren-Yu;Liu, Ze-Kun;Wei, Ding;Yong, Yu-Le;Lin, Peng;...

通讯作者：

Chen, Zhi-Nan;Bian, Huijie

作者机构：

[Yong, Yu-Le; Lin, Peng; Liu, Man; Zheng, Nai-Shan; Li, Hao; Zhang, Ren-Yu; Chen, Zhi-Nan; Bian, Huijie; Liu, Ze-Kun; Wei, Ding] Fourth Mil Med Univ, Natl Translat Sci Ctr Mol Med, Dept Cell Biol, Xian 710032, Peoples R China.

[Liu, Ke] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.

[Yang, Xiao-Zhen; Hu, Cai-Xia] Capital Med Univ, Beijing Youan Hosp, Oncol & Hepatobiliary Minimally Invas Intervent C, Beijing 100069, Peoples R China.

通讯机构：

[Chen, ZN; Bian, HJ] F

Fourth Mil Med Univ, Natl Translat Sci Ctr Mol Med, Dept Cell Biol, Xian 710032, Peoples R China.

语种：

英文

期刊：

信号转导与靶向治疗

ISSN：

2095-9907

年：

2021

卷：

期：

页码：

407-418

DOI：

10.1038/s41392-020-00432-z

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874155]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Genomic sequencing analysis of tumors provides potential molecular therapeutic targets for precision medicine. However, identifying a key driver gene or mutation that can be used for hepatocellular carcinoma (HCC) treatment remains difficult. Here, we performed whole-exome sequencing on genomic DNA obtained from six pairs of HCC and adjacent tissues and identified two novel somatic mutations of UBE2S (p. Gly57Ala and p. Lys63Asn). Predictions of the functional effects of the mutations showed that two amino-acid substitutions were potentially deleterious. Further, we observed that wild-type UBE...

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UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development

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