CRISPR/Cas Systems towards Next-Generation Biosensing

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成果类型：

期刊论文

作者：

Li, Yi;Li, Shiyuan;Wang, Jin*;Liu, Guozhen*

通讯作者：

Liu, Guozhen;Wang, Jin

作者机构：

[Liu, Guozhen; Li, Yi] Univ New South Wales, Fac Engn, ARC Ctr Excellence Nanoscale Biophoton, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia.

[Liu, Guozhen; Li, Yi] Univ New South Wales, Australian Ctr NanoMed, Sydney, NSW 2052, Australia.

[Li, Shiyuan] Shanghai Tolo Biotechnol Co Ltd, Shanghai 200233, Peoples R China.

[Wang, Jin] Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai 200234, Peoples R China.

[Liu, Guozhen] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Liu, Guozhen] U

[Wang, Jin] S

[Liu, Guozhen] C

Univ New South Wales, Fac Engn, ARC Ctr Excellence Nanoscale Biophoton, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia.

Univ New South Wales, Australian Ctr NanoMed, Sydney, NSW 2052, Australia.

语种：

英文

关键词：

CRISPR/Cas;Cas12;Cas13;Cas9;biosensing;diagnostics;nucleic acid detection

期刊：

Trends in Biotechnology

ISSN：

0167-7799

年：

2019

卷：

期：

页码：

730-743

DOI：

10.1016/j.tibtech.2018.12.005

基金类别：

Acknowledgments This work was financially supported by funding from the Australia Research Council Future Fellowship (FT160100039), the ARC Centre of Excellence for Nanoscale BioPhotonics CE140100003, and the National Natural Science Foundation of China (Grant 21575045). Yi Li would like to thank the University of New South Wales for providing PhD Scholarship.

机构署名：

本校为通讯机构

院系归属：

化学学院

摘要：

Beyond its remarkable genome editing ability, the CRISPR/Cas9 effector has also been utilized in biosensing applications. The recent discovery of the collateral RNA cleavage activity of the Cas13a effector has sparked even greater interest in developing novel biosensing technologies for nucleic acid detection and promised significant advances in CRISPR diagnostics. Now, along with the discovery of Cas12 collateral cleavage activities on single-stranded DNA (ssDNA), several CRISPR/Cas systems have been established for detecting various targets, including bacteria, viruses, cancer mutations, and...

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