Degradation of FA reduces A beta neurotoxicity and Alzheimer-related phenotypes

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成果类型：

期刊论文

作者：

Fei, Xuechao;Zhang, Yun;Mei, Yufei;Yue, Xiangpei;Jiang, Wenjing;...

通讯作者：

Tong, Zhiqian;Song, Weihong

作者机构：

[Fei, Xuechao; Yue, Xiangpei; He, Rongqiao; Jiang, Wenjing; Mei, Yufei; Tong, Zhiqian; Ai, Li] Capital Med Univ, Collaborat Innovat Ctr Brain Disorders, Beijing Inst Brain Disorders, Lab Brain Disorders,Alzheimers Dis Ctr,Minist Sci, Beijing 100069, Peoples R China.

[Zhang, Yun; Song, Weihong] Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China.

[Zhang, Yun; Song, Weihong] Univ British Columbia, Dept Psychiat, Townsend Family Labs, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

[Mei, Yufei] Zhejiang Univ, Sch Basic Med Sci, Hangzhou 310058, Peoples R China.

[Lyv, Jihui; Jiang, Wenjing] Beijing Geriatr Hosp, Ctr Cognit Disorders, Beijing 100095, Peoples R China.

通讯机构：

[Tong, Zhiqian; Song, Weihong] C

[Song, Weihong] U

Capital Med Univ, Collaborat Innovat Ctr Brain Disorders, Beijing Inst Brain Disorders, Lab Brain Disorders,Alzheimers Dis Ctr,Minist Sci, Beijing 100069, Peoples R China.

Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China.

Univ British Columbia, Dept Psychiat, Townsend Family Labs, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

语种：

英文

期刊：

Molecular Psychiatry

ISSN：

1359-4184

年：

2020

卷：

期：

页码：

5578-5591

DOI：

10.1038/s41380-020-00929-7

基金类别：

Acknowledgements We thank Prof. Lei Liu of Capital Medical University for his comments. This work was supported by the National Natural Science Foundation of China (82071214); the Beijing Natural Science Foundation of China (7172022); the Scientific Research Common Program of Beijing Municipal Commission of Education (KM201510025014); the Major Projects Fund of Beijing Institute for Brain Disorders (ZD2015-08); and the Canadian Institutes of Health Research (CIHR) Project Grant PJT-166127 (to WS). WS was the holder of the Tier 1 Canada Research Chair in Alzheimer’s Disease.

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本校为其他机构

院系归属：

生命科学学院

摘要：

Dysregulation of formaldehyde (FA) has been implicated in the development of Alzheimer's Disease (AD). Elevated FA levels in Alzheimer's patients and animal models are associated with impaired cognitive functions. However, the exact role of FA in AD remains unknown. We now identified that oxidative demethylation at serine(8/26) of amyloid-beta protein (A beta) induced FA generation and FA cross-linked with the lysine(28) residue in the beta-turn of A beta monomer to form A beta dimers, and then accelerated A beta oligomerization and fibrillogenesis in vitro. However, A beta 42 mutation in seri...

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Degradation of FA reduces A beta neurotoxicity and Alzheimer-related phenotypes

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