期刊论文

Preparation of Cefetamet Pivoxil Hydrochloride Tablets

中文

中国医药工业杂志

Chinese Journal of Pharmaceuticals

1001-8255

2002

33

5

231-232

10.3969/j.issn.1001-8255.2002.05.011

本校为第一机构

盐酸头孢他美匹酯(cefetamet pivoxil hydrochloride,1)为口服头孢菌素,主要用于治疗上、下呼吸道感染和尿路感染及淋病性尿道感染等.目前,1片研究的关键在于解决其溶出度和稳定性问题.由于1遇水后粘性很强,不易制粒压片;同时1遇热、见光易分解、变色.因此,采用常规湿法制粒工艺压片非常困难.我们曾用粉末直接压片,但所得片子的片重差异、溶出度和含量均不合格.本实验通过改进处方工艺,采用特殊湿法制粒工艺制得1片.对其进行质量分析,各项检验结果均符合规定,同时对其进行稳定性考察,结果表明本品在18个月内较稳定.

The formulation and technology of cefetamet pivoxil hydrochloride tablets were presented to solve the problem of low drug release and unstability. The results showed the tablets complied with the standard and could...