Dibutyl phthalate aggravated asthma-like symptoms through oxidative stress and increasing calcitonin gene-related peptide release

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成果类型：

期刊论文

作者：

Zhou, Sangyu;Han, Man;Ren, Yaolin;Yang, Xu;Duan, Liju;...

通讯作者：

Li, Jinquan

作者机构：

[Han, Man; Ren, Yaolin; Li, Jinquan; Zhou, Sangyu; Zeng, Yan] Wuhan Univ Sci & Technol, Sch Med, Brain Sci & Adv Technol Inst, Wuhan 430081, Peoples R China.

[Li, Jinquan] Wuhan Univ Sci & Technol, Sch Med, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Coll Life Sci, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Duan, Liju] Huazhong Univ Sci & Technol, Sch Publ Hlth, Wuhan 430030, Peoples R China.

通讯机构：

[Li, Jinquan] W

Wuhan Univ Sci & Technol, Sch Med, Brain Sci & Adv Technol Inst, Wuhan 430081, Peoples R China.

语种：

英文

关键词：

Allergic asthma;Calcitonin gene-related peptide;Dibutyl phthalate;Melatonin;Oxidative stress

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2020

卷：

199

页码：

110740

DOI：

10.1016/j.ecoenv.2020.110740

基金类别：

This work was funded by the Health Commission of Hubei Province scientific research project, China ( WJ 2019Q057 ).

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Dibutyl phthalate (DBP) is one of the most ubiquitous phthalate esters found in everyday products, and is receiving increased attention as an immunologic adjuvant. However, information regarding DBP-aggravated allergic asthma is still limited. This study used a mouse model sensitized with ovalbumin (OVA) to determine any adverse effects of DBP on allergic asthma. Our results reveal that allergic asthmatic mice exposed to DBP for an extended period had a significant increase in inflammatory cell infiltration; a significant increase in levels of serum immunoglobulin and T helper 2 cell (Th2) and...

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Dibutyl phthalate aggravated asthma-like symptoms through oxidative stress and increasing calcitonin gene-related peptide release

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