On the hypothesis that hetero-sources could involve in self-sorting domino reactions and generate suitably functionalized intermediates to converge on the final product, we present herein a simple model of this strategy for the preparation of unsymmetrical 1,4-dihydropyridines. In the presence of CH(3)COONH(4) and 3-nitrobenzaldehyde, two different 1,3-dicarbonyl compounds, respectively, generate the enamine and enone intermediates, which could finally combine with each other to efficiently afford the unsymmetrical 1,4-dihydropyridines. Direct (1)H NMR analysis of the reaction mixture further ...
