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Resonance effects in neuronal-astrocyte model with ion channel blockage

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成果类型:
期刊论文
作者:
Xiao, Fangli;Fu, Ziying;Jia, Ya;Yang, Lijian
通讯作者:
Yang, LJ
作者机构:
[Xiao, Fangli; Yang, LJ; Yang, Lijian; Jia, Ya] Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan 430079, Peoples R China.
[Fu, Ziying] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构:
[Yang, LJ ] C
Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Channel blockage;Resonance;Astrocyte;Frequency dependence
期刊:
CHAOS SOLITONS & FRACTALS
ISSN:
0960-0779
年:
2023
卷:
166
页码:
112969
基金类别:
CRediT authorship contribution statement Fangli Xiao: Conceptualization, Methodology, Formal analysis, Investigation, Data curation, Writing – original draft, Visualization, Writing – review & editing. Ziying Fu: Validation, Visualization, Formal analysis. Ya Jia: Resources, Supervision, Project administration, acquisition. Lijian Yang: Resources, Validation, Supervision, Formal analysis, Writing – review & editing, Project administration.
机构署名:
本校为第一且通讯机构
院系归属:
物理科学与技术学院
生命科学学院
摘要:
Blockage of the specific ion channel is significant for neuronal dynamics. Astrocytes, the active partners of neurons, play the role of regulators of many neural activity processes. The effects of ion channel blockage and astrocyte responses to subthreshold periodic signals of different frequencies were investigated in a stochastic extended Hodgkin-Huxley model. We demonstrated that the neuronal response to weak signals is weakened by sodium channel blockage, whereas it is improved by modulating the degree of potassium channel blockage. There i...

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