Antibacterial activity and mechanism of ThDP analogs against rice brown stripe pathogen Acidovorax avenae subsp. avenae RS-1

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成果类型：

期刊论文

作者：

Wang, Xiao Xuan;Qi, Hang Ying;Chen, Jie;Yang, Ying Zi;Qiu, Wen*;...

通讯作者：

Qiu, Wen;Sun, Guo Chang

作者机构：

[Li, Bin; Wang, Xiao Xuan; Yang, Ying Zi; Chen, Jie; Qiu, Wen] Zhejiang Univ, Inst Biotechnol, Key Lab Mol Biol Crop Pathogens & Insects, State Key Lab Rice Biol,Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China.

[Qi, Hang Ying] Zhuji Extens & Serv Ctr Agr Tech, Zhuji 310020, Peoples R China.

[He, Hong Wu; Wang, Wei; Zou, Peng] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.

[He, Hong Wu; Wang, Wei; Zou, Peng] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.

[Sun, Guo Chang; Wang, Yan Li] Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China.

通讯机构：

[Qiu, Wen; Sun, Guo Chang] Z

Zhejiang Univ, Inst Biotechnol, Key Lab Mol Biol Crop Pathogens & Insects, State Key Lab Rice Biol,Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China.

Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China.

语种：

英文

关键词：

Chemical;Rice bacterial brown stripe pathogen;Gene expression;Action mode

期刊：

Journal of Plant Pathology

ISSN：

1125-4653

年：

2019

卷：

101

期：

页码：

59-69

DOI：

10.1007/s42161-018-0137-4

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571971, 31371904, 21472062]; Zhejiang Provincial Project [2017C02002]; National Key Research and Development Program of China [2017YFD0201104]; Shanghai Agricultural Basic Research Project [2014:7-3-1]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Agricultural Ministry of ChinaMinistry of Agriculture, China [nyhyzx 201303015]; National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126100]; Dabeinong Funds for Discipline Development and Talent Training in Zhejiang University; Key Subject Construction Program of Zhejiang for Modern Agricultural Biotechnology and Crop Disease Control [2010DS700124-KF1710]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017 M612003]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Thiamin diphosphate (ThDP) analogs have been designed and synthesized based on the ThDP binding site of the pyruvate dehydrogenase multienzyme complex E1 of Escherichia coli. This study investigated the effect of 66 novel ThDP analogs on rice bacterial brown stripe pathogen Acidovorax avenae subsp. avenae strain RS-1. Results indicated that three of the 66 ThDP analogs (designated as 20, 21 and 53) significantly inhibited the in vitro growth of strain RS-1. However, no obvious cell lysis and destruction was found for this rice pathogenic bacterium, which were supported by morphological evidenc...

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Antibacterial activity and mechanism of ThDP analogs against rice brown stripe pathogen Acidovorax avenae subsp. avenae RS-1

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